Detection of protein-protein interactions in vivo based on protein splicing

被引：39

作者：

Ozawa, T ^{[1
]}

Umezawa, Y

机构：

[1] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Corp, Tokyo, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/S1367-5931(00)00244-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, protein-protein interactions constitute essential regulatory steps that modulate the activity of signaling pathways. In recent years, several approaches towards understanding the interactions have been developed. We describe herein a new method for detecting protein-protein interactions in vivo based on protein splicing and highlight some potential applications of this technique.

引用

页码：578 / 583

页数：6

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