Biological Activities of Indian Celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh

被引：23

作者：

Abbaskhan, Ahmed ^{[1
]}

Choudhary, Muhammed Iqbal ^{[1
,2
]}

Ghayur, Mohammed Nabeel ^{[3
]}

Parween, Zeba ^{[1
]}

Shaheen, Farzana ^{[1
]}

Gilani, Anwar-ul-Hassan ^{[3
]}

Maruyama, Takuro ^{[4
]}

Iqbal, Kiran ^{[1
]}

Tsuda, Yoshisuke ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

[3] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi 74800, Pakistan

[4] Natl Inst Hlth Sci, Div Pharmacognosy Phytochem & Narcot, Setagaya Ku, Tokyo 1588501, Japan

来源：

PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 05期

关键词：

Indian celery; Seseli diffusum; cytotoxicity; spasmolytic activity; spasmogenic activity; antioxidant activity; ANTHRISCUS-SYLVESTRIS HOFFM; NATURAL-PRODUCTS; ROOT;

D O I：

10.1002/ptr.3600

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOHH2O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant. Copyright (c) 2011 John Wiley & Sons, Ltd.

引用

页码：783 / 786

页数：4

共 15 条

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