Antigen adsorbed calcium phosphate nanoparticles stimulate both innate and adaptive immune response in fish, Labeo rohita H.

被引:23
作者
Behera, Truptimayee [1 ]
Swain, Priyabrat [1 ]
机构
[1] Cent Inst Freshwater Aquaculture, Fish Hlth Management Div, Bhubaneswar 751002, Orissa, India
关键词
Antigen; Adjuvant; Adaptive immunity; Aeromonas hydrophila; Calcium phosphate; Fish; Innate immunity; Nanoparticle; Parenteral immunization; S-layer protein; CYPRINUS-CARPIO L; AEROMONAS-HYDROPHILA; IMMUNOLOGICAL ADJUVANTS; CAMPYLOBACTER-FETUS; ALUMINUM-HYDROXIDE; PROTEINS; HYDROXYAPATITE; PROTECTION; MICROPARTICLES; TRANSFECTION;
D O I
10.1016/j.cellimm.2011.07.015
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Calcium phosphate nanoparticles as an antigen/protein delivery was explored in a fish model Labeo rohita H. S-layer protein (of Aeromonas hydrophila) adsorbed on nano sized calcium phosphate particles elicited both innate and adaptive immune parameters which persisted up to 63 days of post immunization through parenteral immunization and gave cross protections. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:350 / 359
页数:10
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