Storage and release of ibuprofen drug molecules in hollow mesoporous silica spheres with modified pore surface

被引:259
作者
Zhu, YF [1 ]
Shi, JL [1 ]
Li, YS [1 ]
Chen, HR [1 ]
Shen, WH [1 ]
Dong, XP [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
基金
中国国家自然科学基金;
关键词
hollow mesoporous spheres; drug release; modification; ibuprofen;
D O I
10.1016/j.micromeso.2005.06.015
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Hollow mesoporous silica spheres with cubic pore network (HMSC) with and without modification using 3-aminopropyltriethoxysilane (N-TES), 3-(2-aminoethylamino)propyltrimethoxysilane (NN-TES) and (3-trimethoxysilylpropyl)diethylenetriamine (NNN-TES) have been successfully synthesized by a simple one-step method and post-modification. The structures, ibuprofen (IBU) drug storage capacities and release rates were characterized and investigated with various techniques. The highest storage amount of 969 mg/g has been obtained by using hexane as solvent and these drug release systems all have a sustained-release property. With the increase of the amount of functional groups introduced, the drug storage capacity decreases and meanwhile the release rate becomes lower. At the same amount of functional groups, the release rate from NNN-HMSC-IBU system (ibuprofen-loaded in NNN-TES modified HMSC) is the lowest. According to the Koorsmeyer-Peppas model, and it is found that the release process of HMSG-IBU system (ibuprofen-loaded in as-prepared HMSC) follows a Fick's law and modified HMSG-IBU systems follow an anomalous non-Fick's transport, respectively. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:75 / 81
页数:7
相关论文
共 27 条
[21]   A new property of MCM-41:: Drug delivery system [J].
Vallet-Regi, M ;
Rámila, A ;
del Real, RP ;
Pérez-Pariente, J .
CHEMISTRY OF MATERIALS, 2001, 13 (02) :308-311
[22]   A reliable synthesis of cubic mesoporous MCM-48 molecular sieve [J].
Xu, J ;
Luan, ZH ;
He, HY ;
Zhou, WZ ;
Kevan, L .
CHEMISTRY OF MATERIALS, 1998, 10 (11) :3690-3698
[23]  
Yang CM, 2002, ADV FUNCT MATER, V12, P143, DOI 10.1002/1616-3028(20020201)12:2<143::AID-ADFM143>3.0.CO
[24]  
2-A
[25]   A new thioether functionalized organic-inorganic mesoporous composite as a highly selective and capacious Hg2+ adsorbent [J].
Zhang, LX ;
Zhang, WH ;
Shi, JL ;
Hua, Z ;
Li, YS ;
Yan, J .
CHEMICAL COMMUNICATIONS, 2003, (02) :210-211
[26]   Direct synthesis and characterization of titanium-substituted mesoporous molecular sieve SBA-15 [J].
Zhang, WH ;
Lu, JQ ;
Han, B ;
Li, MJ ;
Xiu, JH ;
Ying, PL ;
Li, C .
CHEMISTRY OF MATERIALS, 2002, 14 (08) :3413-3421
[27]   Comprehensive study of surface chemistry of MCM-41 using Si-29 CP/MAS NMR, FTIR, pyridine-TPD, and TGA [J].
Zhao, XS ;
Lu, GQ ;
Whittaker, AK ;
Millar, GJ ;
Zhu, HY .
JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (33) :6525-6531