Non-small-cell lung cancer and miRNAs: novel biomarkers and promising tools for treatment

被引：64

作者：

Feng, Bing ^{[1
]}

Zhang, Kai ^{[1
]}

Wang, Rui ^{[1
]}

Chen, Longbang ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Med Oncol, Nanjing 210008, Jiangsu, Peoples R China

来源：

CLINICAL SCIENCE | 2015年 / 128卷 / 10期

基金：

中国国家自然科学基金;

关键词：

diagnosis; individualized treatment; miRNA; non-small; cell lung cancer (NSCLC); post-transcriptional regulation; prognosis; RB-DEPENDENT MANNER; LONG NONCODING RNA; TUMOR-SUPPRESSOR; ADENOCARCINOMA CELLS; MESENCHYMAL TRANSITION; BREAST-CANCER; ACQUIRED-RESISTANCE; E-CADHERIN; GEFITINIB RESISTANCE; EXPRESSION SIGNATURE;

D O I：

10.1042/CS20140530

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lung cancer is the leading cause of cancer-related death worldwide, with approximately 80-85% of cases being non-small-cell lung cancer (NSCLC). The miRNAs are small non-coding RNAs that regulate gene expression at a post-transcriptional level by either degradation or inhibition of the translation of target genes. Evidence is mounting that miRNAs exert pivotal effects in the development and progression of human malignancies, including NSCLC. A better understanding of the role that miRNAs play in the disease will contribute to the development of new diagnostic biomarkers and individualized therapeutic tools. In the present review, we briefly describe the role of miRNAs in NSCLC as well as the possible future of these discoveries in clinical applications.

引用

页码：619 / 634

页数：16

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