miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein

被引：66

作者：

Guo, Yan ^{[1
,2
]}

Fu, Weineng ^{[1
]}

Chen, Hong ^{[1
]}

Shang, Chao ^{[3
]}

Zhong, Ming ^{[2
]}

机构：

[1] China Med Univ, Dept Med Genet, Shenyang 110001, Peoples R China

[2] China Med Univ, Sch Stomatol, Dept Cent Lab, Shenyang 110007, Peoples R China

[3] China Med Univ, Dept Neurobiol, Shenyang 110001, Peoples R China

来源：

ONCOLOGY REPORTS | 2012年 / 27卷 / 04期

关键词：

laryngeal squamous cell carcinoma; miR-24; S100A8; invasion; translational regulation; CANCER; MICRORNAS; BINDING; CARCINOGENESIS; INFLAMMATION; ACTIVATION; PATHWAY; GENES; HEAD;

D O I：

10.3892/or.2011.1571

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

microRNAs, a family of small non-coding RNAs, regulating approximately 30% of all human genes are deeply involved in the pathogenesis of several types of cancers, including laryngeal squamous cell carcinoma (LSCC). Here, we demonstrate that miR-24 is down-regulated in human LSCC tissues. Ectopic expression of miR-24 in Hep2 cells significantly induced cell morphology changes and inhibited cell proliferation and invasion ability in vitro by targeting S100A8 at the translational level. Meanwhile, miR-24 could significantly inhibit Hep2 cell invasion after S100A8 protein blockade. In conclusion, our results suggest that miR-24 may function as a tumor suppressor in LSCC through down-regulation of S100A8, which suggests that miR-24 could serve as a novel potential maker for LSCC therapy.

引用

页码：1097 / 1103

页数：7

共 28 条

[1]

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