A new universal solid support for oligonucleotide synthesis

被引：24

作者：

Azhayev, AV ^{[1
]}

机构：

[1] Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland

来源：

TETRAHEDRON | 1999年 / 55卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(98)01071-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 2,3:5,6-di-O-isopropylidene-alpha-D-mannofuranose, benzyl 5,6-ditrifluoroacetamido-5,6-dideoxy-2-O-(4,4'-dimethoxytrityl)-alpha-D-mannofuranose was prepared and attached to a controlled pore glass to generate a new universal solid support for oligonucleotide synthesis. This support is applicable for the preparation of all types of oligonucleotides as well as oligomers with unusual base-libile nucleosides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：787 / 800

页数：14

共 11 条

[1]

ATKINSON T, 1984, OLIGONUCLEOTIDE SYNT, P47

[2]

ATKINSON T, 1984, OLIGONUCLEOTIDE SYNT, P35

[3] PUROMYCIN - SYNTHETIC STUDIES .13. SYNTHESIS OF 6-DIMETHYLAMINO-9-(3'-AMINO-3'-DEOXY-BETA-D-ARABINOFURANOSYL)-PURINE [J].

BAKER, BR ;

SCHAUB, RE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (22) :5900-5905

[4]

HOGFELDT E, 1982, STABILITY CONSTANTS, P111

[5] Kinetic analysis of diamine-catalyzed RNA hydrolysis [J].

Komiyama, M ;

Yoshinari, K .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (07) :2155-2160

[6] Stereospecific synthesis of β-D-fructofuranosides using thioglycoside donors and internal aglycon delivery [J].

Krog-Jensen, C ;

Oscarson, S .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (06) :1780-1784

[7]

KUUSELA S, 1998, J CHEM SOC P2, P2301

[8]

PERRIN DD, 1979, STABILITY CONSTANT B, P63

[9] Hydroquinone-O,O'-diacetic acid as a more labile replacement for succinic acid linkers in solid-phase oligonucleotide synthesis [J].

Pon, RT ;

Yu, SY .

TETRAHEDRON LETTERS, 1997, 38 (19) :3327-3330

[10]

SCOTT S, 1994, PERSPECTIVES SOLID P, P115

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