P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

被引：93

作者：

Scarborough, PE ^{[1
]}

Ma, JX ^{[1
]}

Qu, W ^{[1
]}

Zeldin, DC ^{[1
]}

机构：

[1] NIEHS, Pulm Pathobiol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

DRUG METABOLISM REVIEWS | 1999年 / 31卷 / 01期

关键词：

D O I：

10.1081/DMR-100101915

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.

引用

页码：205 / 234

页数：30

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