P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

被引：93

作者：

Scarborough, PE ^{[1
]}

Ma, JX ^{[1
]}

Qu, W ^{[1
]}

Zeldin, DC ^{[1
]}

机构：

[1] NIEHS, Pulm Pathobiol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

DRUG METABOLISM REVIEWS | 1999年 / 31卷 / 01期

关键词：

D O I：

10.1081/DMR-100101915

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.

引用

页码：205 / 234

页数：30

共 87 条

[51] Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4 [J].

Ma, JX ;

Ramachandran, S ;

Fiedorek, FT ;

Zeldin, DC .

GENOMICS, 1998, 49 (01) :152-155

[52] AN EPOXYGENASE METABOLITE OF ARACHIDONIC-ACID MEDIATES ANGIOTENSIN-II-INDUCED RISES IN CYTOSOLIC CALCIUM IN RABBIT PROXIMAL TUBULE EPITHELIAL-CELLS [J].

MADHUN, ZT ;

GOLDTHWAIT, DA ;

MCKAY, D ;

HOPFER, U ;

DOUGLAS, JG .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (02) :456-461

[53] EXPERIMENTAL AND/OR GENETICALLY CONTROLLED ALTERATIONS OF THE RENAL MICROSOMAL CYTOCHROME-P450 EPOXYGENASE INDUCE HYPERTENSION IN RATS FED A HIGH-SALT DIET [J].

MAKITA, K ;

TAKAHASHI, K ;

KARARA, A ;

JACOBSON, HR ;

FALCK, JR ;

CAPDEVILA, JH .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2414-2420

[54] CYTOCHROME-P-450 METABOLISM OF ARACHIDONIC-ACID [J].

MCGIFF, JC .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1991, 31 :339-369

[55] THE CONTRIBUTION OF CYTOCHROME P450-DEPENDENT ARACHIDONATE METABOLITES TO INTEGRATED RENAL-FUNCTION [J].

MCGIFF, JC ;

QUILLEY, CP ;

CARROLL, MA .

STEROIDS, 1993, 58 (12) :573-579

[56] Structural flexibility and functional versatility of mammalian P450 enzymes [J].

Negishi, M ;

Uno, T ;

Darden, TA ;

Sueyoshi, T ;

Pedersen, LG .

FASEB JOURNAL, 1996, 10 (07) :683-689

[57] P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature [J].

Nelson, DR ;

Koymans, L ;

Kamataki, T ;

Stegeman, JJ ;

Feyereisen, R ;

Waxman, DJ ;

Waterman, MR ;

Gotoh, O ;

Coon, MJ ;

Estabrook, RW ;

Gunsalus, IC ;

Nebert, DW .

PHARMACOGENETICS, 1996, 6 (01) :1-42

[58]

OJEDA SR, 1989, ANN NY ACAD SCI, V559, P192, DOI DOI 10.1111/J.1749-6632.1989.TB22609.X

[59]

OLEKSIAK MF, UNPUB

[60] OXYGENATION OF POLYUNSATURATED FATTY-ACIDS BY CYTOCHROME-P450 MONOOXYGENASES [J].

OLIW, EH .

PROGRESS IN LIPID RESEARCH, 1994, 33 (03) :329-354

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