Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control

被引：166

作者：

Lee, Jeannie T. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Howard Hughes Med Inst,Dept Mol Biol,Dept Genet, Boston, MA 02114 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 12期

关键词：

LONG NONCODING RNA; DOSAGE COMPENSATION; XIST RNA; FACULTATIVE HETEROCHROMATIN; TSIX TRANSCRIPTION; SEX-CHROMOSOMES; GERM-CELLS; ANTISENSE TRANSCRIPTION; COUNTING PROCESS; DNA METHYLATION;

D O I：

10.1038/nrm3231

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The discovery of X-chromosome inactivation (XCI) celebrated its golden anniversary this year. Originally offered as an explanation for the establishment of genetic equality between males and females, 50 years on, XCI presents more than a curious gender-based phenomenon that causes silencing of sex chromosomes. How have the mysteries of XCI unfolded? And what general lessons can be extracted? Several of the cell biological mechanisms that are used to establish the inactive X chromosome, including regulatory networks of non-coding RNAs and unusual nuclear dynamics, are now suspected to hold true for processes occurring on a genome-wide scale.

引用

页码：815 / 826

页数：12

共 200 条

[1]

EXPRESSION OF ALPHA-GALACTOSIDASE IN PREIMPLANTATION MOUSE EMBRYOS [J].

ADLER, DA ;

WEST, JD ;

CHAPMAN, VM .

NATURE, 1977, 267 (5614) :838-839

[2]

SATB1 Defines the Developmental Context for Gene Silencing by Xist in Lymphoma and Embryonic Cells [J].

Agrelo, Ruben ;

Souabni, Abdallah ;

Novatchkova, Maria ;

Haslinger, Christian ;

Leeb, Martin ;

Komnenovic, Vukoslav ;

Kishimoto, Hiroyuki ;

Gresh, Lionel ;

Kohwi-Shigematsu, Terumi ;

Kenner, Lukas ;

Wutz, Anton .

DEVELOPMENTAL CELL, 2009, 16 (04) :507-516

[3]

X-chromosome kiss and tell: How the Xs go their separate ways [J].

Anguera, M. C. ;

Sun, B. K. ;

Xu, N. ;

Lee, J. T. .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2006, 71 :429-437

[4]

Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain [J].

Anguera, Montserrat C. ;

Ma, Weiyuan ;

Clift, Danielle ;

Namekawa, Satoshi ;

Kelleher, Raymond J., III ;

Lee, Jeannie T. .

PLOS GENETICS, 2011, 7 (09)

[5]

[Anonymous], 1964, On the origin of species by means of natural selection, of the preservation of favoured races in the struggle of life

[6]

Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic [J].

Augui, S. ;

Filion, G. J. ;

Huart, S. ;

Nora, E. ;

Guggiari, M. ;

Maresca, M. ;

Stewart, A. F. ;

Heard, E. .

SCIENCE, 2007, 318 (5856) :1632-1636

[7]

Molecular correlates of the murine Xce locus [J].

Avner, P ;

Prissette, M ;

Arnaud, D ;

Courtier, B ;

Cecchi, C ;

Heard, E .

GENETICS RESEARCH, 1998, 72 (03) :217-224

[8]

Bacher CP, 2006, NAT CELL BIOL, V8, P293, DOI 10.1038/ncb1365

[9]

Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis [J].

Bailey, JA ;

Carrel, L ;

Chakravarti, A ;

Eichler, EE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6634-6639

[10]

THEODOR BOVERI [J].

BALTZER, F .

SCIENCE, 1964, 144 (362) :809-&

← 1 2 3 4 5 6 7 8 9 10 →