Dam methylation: coordinating cellular processes

被引：191

作者：

Lobner-Olesen, A

Skovgaard, O

Marinus, MG

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

[2] Rosklide Univ, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark

来源：

CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1016/j.mib.2005.02.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.

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页码：154 / 160

页数：7

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