Fractal and reactive dimension of a diclofenac salt: Effect of the experimental conditions

被引：4

作者：

FernandezHervas, MJ ^{[1
]}

Holgado, MA ^{[1
]}

Rabasco, AM ^{[1
]}

Fazio, G ^{[1
]}

Fini, A ^{[1
]}

机构：

[1] UNIV BOLOGNA,IST SCI CHIM,BOLOGNA,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 136卷 / 1-2期

关键词：

diclofenac/N-(2-hydroxyethyl)pyrrolidine; surface geometry; fractal dimension; reactive dimension;

D O I：

10.1016/0378-5173(96)04498-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The characterization of five samples from different batches of the same salt, Diclofenac/N-(2-hydroxyethyl)pyrrolidine, was realized by means of fractal analysis. When the samples were subjected to weak heating, the fractal dimension of the surface obtained, before and after thermal treatment, suggest that no great modifications occurred on the particles surface. On the contrary, the analysis of reactive dimension toward dissolution, D-R, showed that much more reactive points appear on the particles surface after the heating process. Different values of D-R were obtained as result of changes in the composition of the dissolution medium.

引用

页码：101 / 106

页数：6

共 10 条

[1] REACTIVE FRACTAL SURFACES [J].