Calix[4]arene decorated with four tn antigen glycomimetic units and P3CS immunoadjuvant:: Synthesis, characterization, and anticancer immunological evaluation

被引：62

作者：

Geraci, Corrada ^{[1
]}

Consoli, Grazia M. L. ^{[1
]}

Galante, Eva ^{[1
]}

Bousquet, Ennio ^{[2
]}

Pappalardo, Maria ^{[2
]}

Spadaro, Angelo ^{[2
]}

机构：

[1] CNR, Ist Chim Biomol, I-95028 Valverde, CT, Italy

[2] Univ Catania, Dipartimento Sci Farmaceut, I-95125 Catania, Italy

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 03期

关键词：

D O I：

10.1021/bc700411w

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized. Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix[4]arene scaffold bearing an immunoadjuvant moiety (P3CS). The immunogenicity of the synthetic construct has been investigated by immunization of mice in vivo. ELISA assay has evidenced that the tetravalent construct stimulates a higher production of anti-Tn antigen IgG antibodies when compared to an analogous monovalent compound. This result is ascribable to an antigen cluster effect and makes the reported vaccine candidate a good mimic of the natural motifs present on the mucine surface.

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收藏

页码：751 / 758

页数：8

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