Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers)

被引：15

作者：

Ahmadvand, Davoud ^{[1
]}

Rahbarizadeh, Fatemeh ^{[2
]}

Moghimi, Seyed Moein ^{[1
]}

机构：

[1] Univ Copenhagen, Ctr Pharmaceut Nanotechnol & Nanotoxicol, DK-2100 Copenhagen O, Denmark

[2] Tarbiat Modares Univ, Dept Med Biotechnol, Fac Med Sci, Tehran, Iran

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2011年 / 22卷 / 06期

关键词：

IN-VITRO SELECTION; CANCER-CELLS; TUMOR-GROWTH; DELIVERY; DNA; LIGANDS; SIRNAS; VIVO; OPTIMIZATION; DISCOVERY;

D O I：

10.1016/j.copbio.2011.02.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Diverse technologies such as phage display, cell systematic evolution of ligands by exponential enrichment and related modifications thereof are generating a wide range of peptide-based and structured nucleic acid (aptamers)-based ligands for therapeutic and diagnostic interventions in an unbiased biological context. Their impressive affinity and unprecedented target specificity make these ligands as ideal small-sized candidates for conjugation to macromolecules and nanoparticulate matters, thus opening the path to new and sophisticated design solutions for targeted therapy, disease detection and diagnosis. Vascular beds of many organs and tissue, cancer, immune and stem cells are among the key targets. These technologies are evaluated and selected recent examples of innovative biological targeting and therapeutic interventions with phage-displayed peptides and aptamers are discussed.

引用

页码：832 / 838

页数：7

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