Phototriggering of cell adhesion by caged cyclic RGD peptides

被引：168

作者：

Petersen, Svea ^{[1
,2
]}

Alonso, Jose Maria ^{[1
]}

Specht, Alexandre ^{[2
]}

Duodu, Portia ^{[2
]}

Goeldner, Maurice ^{[2
]}

del Campo, Aranzazu ^{[1
]}

机构：

[1] Max Planck Inst Met Res, D-70569 Stuttgart, Germany

[2] Univ Strasbourg 1, Chim Bioorgan Lab, CNRS, Fac Pharm,UMR7175, F-67401 Illkirch Graffenstaden, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 17期

关键词：

cage compounds; cell adhesion; peptides; photolysis; responsive surfaces;

D O I：

10.1002/anie.200704857

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Restrained potential: A caged cyclic peptide attached to a surface is able to trigger cell attachment to the surface with spatiotemporal definition upon exposure to light (λ = 351 nm). The peptide shows no integrin-binding activity in its caged form, but mediates cell adhesion effectively after irradiation (see optical microscopy image of cells on a surface irradiated through a mask in bands 100 μm in width). (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3192 / 3195

页数：4

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