Early osteoarthritis of the knee

被引：237

作者：

Madry, Henning ^{[1
,2
]}

Kon, Elizaveta ^{[3
]}

Condello, Vincenzo ^{[4
]}

Peretti, Giuseppe M. ^{[5
,6
]}

Steinwachs, Matthias ^{[7
]}

Seil, Romain ^{[8
]}

Berruto, Massimo ^{[9
]}

Engebretsen, Lars ^{[10
,11
]}

Filardo, Giuseppe ^{[12
]}

Angele, Peter ^{[13
,14
]}

机构：

[1] Univ Saarland, Ctr Expt Orthopaed, Kirrberger Str 100,Bldg 37-38, D-66421 Homburg, Germany

[2] Univ Saarland, Dept Orthopaed Surg, Med Ctr, Kirrberger Str 100,Bldg 37-38, D-66421 Homburg, Germany

[3] Rizzoli Orthopaed Inst, NABI Lab, Via Di Barbiano 1-10, I-40136 Bologna, Italy

[4] Osped Sacro Cuore Don Calabria, Dipartimento Ortoped, Strut Semplice Traumatol, Sport Knee Surg & Sports Traumatol, Via Don,Sempreboni 5, I-37024 Verona, Italy

[5] IRCCS Ist Ortoped Galeazzi, Milan, Italy

[6] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[7] Klin Hirslanden, SportClin Zurich, Witellikerstr 40, CH-8032 Zurich, Switzerland

[8] Ctr Hosp Luxembourg, Luxembourg Inst Hlth,Res Lab, Ctr Appareil Locomoteur Med Sport & Prevent, Serv Chirurg Orthoped,Clin Eich & Sports Med, 78 Rue Eich, L-1460 Luxembourg, Luxembourg

[9] Azienda Osped Rilievo Nazl, Ctr Eccellenza Att Ortoped Reumatol & Riabilitat, Ist Ortoped Gaetano Pini, Pzza A Ferrari 1, I-20122 Milan, Italy

[10] Oslo Univ Hosp, Dept Orthoped Surg, N-0407 Oslo, Norway

[11] Oslo Sports Trauma Res Ctr, N-0407 Oslo, Norway

[12] Rizzoli Orthopaed Inst, Orthopaed & Traumatol Clin 2, Biomech Lab, Via Di Barbiano 1-10, I-40136 Bologna, Italy

[13] Univ Med Ctr Regensburg, Dept Trauma Surg, Franz Josef Str Allee 11, D-93042 Regensburg, Germany

[14] Sporthopaedicum Regensburg, Hildegard von Bingen Str 1, D-93053 Regensburg, Germany

来源：

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY | 2016年 / 24卷 / 06期

关键词：

OA; Pain; Osteochondral unit; Cartilage; Subchondral bone; Meniscus; Traumatic lesion; Classification; Focal cartilage defect; Biomarkers; SUPERFICIAL ZONE PROTEIN; BODY-MASS INDEX; ARTICULAR-CARTILAGE; RADIOGRAPHIC PROGRESSION; BONE; BIOMARKERS; SEVERITY; FRICTION; PREDICTS; KELLGREN;

D O I：

10.1007/s00167-016-4068-3

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

There is an increasing awareness on the importance in identifying early phases of the degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when there might still be the possibility to initiate treatments preventing its progression. Early OA may show a diffuse and ill-defined involvement, but also originate in the cartilage surrounding a focal lesion, thus necessitating a separate assessment of these two entities. Early OA can be considered to include a maximal involvement of 50 % of the cartilage thickness based on the macroscopic ICRS classification, reflecting an OARSI grade 4. The purpose of this paper was to provide an updated review of the current status of the diagnosis and definition of early knee OA, including the clinical, radiographical, histological, MRI, and arthroscopic definitions and biomarkers. Based on current evidence, practical classification criteria are presented. As new insights and technologies become available, they will further evolve to better define and treat early knee OA. Level of evidence IV.

引用

页码：1753 / 1762

页数：10

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