Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyr4 and parC

被引：66

作者：

Gibreel, A

Sjögren, E

Kaijser, B

Wretlind, B

Sköld, O

机构：

[1] Univ Uppsala, Ctr Biomed, Dept Pharmaceut Biosci, Div Microbiol, S-75123 Uppsala, Sweden

[2] Univ Gothenburg, Dept Clin Bacteriol, Gothenburg, Sweden

[3] Karolinska Hosp, Bacteriol Lab, S-10401 Stockholm, Sweden

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 12期

关键词：

D O I：

10.1128/AAC.42.12.3276

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 mu g of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product.

引用

页码：3276 / 3278

页数：3

共 24 条

[21] CLONING AND NUCLEOTIDE-SEQUENCE OF THE CAMPYLOBACTER-JEJUNI GYRA GENE AND CHARACTERIZATION OF QUINOLONE RESISTANCE MUTATIONS [J].