Decoding calcium signals involved in cardiac growth and function

被引：282

作者：

Frey, N ^{[1
]}

McKinsey, TA ^{[1
]}

Olson, EN ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/81321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.

引用

页码：1221 / 1227

页数：7

共 80 条

[31] Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts [J].

Kirchhefer, U ;

Schmitz, W ;

Scholz, H ;

Neumann, J .

CARDIOVASCULAR RESEARCH, 1999, 42 (01) :254-261

[32] MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium [J].

Kolodziejczyk, SM ;

Wang, L ;

Balazsi, K ;

Derepentigny, Y ;

Kothary, R ;

Megeney, LA .

CURRENT BIOLOGY, 1999, 9 (20) :1203-1206

[33] Phospholamban: A prominent regulator of myocardial contractility [J].

Koss, KL ;

Kranias, EG .

CIRCULATION RESEARCH, 1996, 79 (06) :1059-1063

[34]

Kuo MH, 1998, BIOESSAYS, V20, P615, DOI 10.1002/(SICI)1521-1878(199808)20:8<615::AID-BIES4>3.0.CO

[35]

2-H

[36] Calcineurin and human heart failure [J].

Lim, HW ;

Molkentin, JD .

NATURE MEDICINE, 1999, 5 (03) :246-247

[37] THE CAM KINASE-II HYPOTHESIS FOR THE STORAGE OF SYNAPTIC MEMORY [J].

LISMAN, J .

TRENDS IN NEUROSCIENCES, 1994, 17 (10) :406-412

[38] Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases [J].

Lu, JR ;

McKinsey, TA ;

Nicol, RL ;

Olson, EN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4070-4075

[39] Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons [J].

Mao, ZX ;

Wiedmann, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :31102-31107

[40] PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts [J].

Marx, SO ;

Reiken, S ;

Hisamatsu, Y ;

Jayaraman, T ;

Burkhoff, D ;

Rosemblit, N ;

Marks, AR .

CELL, 2000, 101 (04) :365-376

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