Decoding calcium signals involved in cardiac growth and function

被引：282

作者：

Frey, N ^{[1
]}

McKinsey, TA ^{[1
]}

Olson, EN ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/81321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.

引用

页码：1221 / 1227

页数：7

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