Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

被引:110
作者
Bazan, Nicolas G. [1 ,2 ]
Calandria, Jorgelina M. [1 ,2 ]
Serhan, Charles N. [3 ,4 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 70112 USA
[2] Louisiana State Univ, Dept Ophthalmol, Sch Med, Hlth Sci Ctr, New Orleans, LA 70112 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
age-related macular degeneration; retinal pigment epithelial cells; oxidative stress; neurotrophins; 15-lipoxygenase-1; RETINAL-PIGMENT EPITHELIUM; POLYUNSATURATED FATTY-ACIDS; COMPLEMENT FACTOR-H; ARACHIDONOYL-COENZYME-A; PRORESOLVING LIPID MEDIATORS; OUTER SEGMENT PHAGOCYTOSIS; ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; OXIDATIVE STRESS; ANTIINFLAMMATORY PROPERTIES;
D O I
10.1194/jlr.R001131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Retinal degenerative diseases result in retinal pigment epithelial (RPE) and photoreceptor cell loss. These cells are continuously exposed to the environment (light) and to potentially pro-oxidative conditions, as the retina's oxygen consumption is very high. There is also a high flux of docosahexaenoic acid (DHA), a PUFA that moves through the blood stream toward photoreceptors and between them and RPE cells. Photoreceptor outer segment shedding and phagocytosis intermittently renews photoreceptor membranes. DHA is converted through 15-lipoxygenase-1 into neuroprotectin D1 (NPD1), a potent mediator that evokes counteracting cell-protective, anti-inflammatory, pro-survival repair signaling, including the induction of anti-apoptotic proteins and inhibition of pro-apoptotic proteins. Thus, NPD1 triggers activation of signaling pathway/s that modulate/s pro-apoptotic signals, promoting cell survival. This review provides an overview of DHA in photoreceptors and describes the ability of RPE cells to synthesize NPD1 from DHA. It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis.-Bazan, N. G., J. M. Calandria, and C. N. Serhan. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J. Lipid Res. 2010. 51: 2018-2031.
引用
收藏
页码:2018 / 2031
页数:14
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