Lithium chloride-catalyzed selective demethylation of aryl methyl ethers under microwave irradiation

被引：27

作者：

Fang, Zhuan ^{[1
]}

Zhou, Guo-Chuan ^{[1
]}

Zheng, Shi-Long ^{[1
]}

He, Guang-Li ^{[1
]}

Li, Ju-Lian ^{[1
]}

He, Ling ^{[1
]}

Bei, Di ^{[1
]}

机构：

[1] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Key Lab Drug Targeting Educ Minist China, Chengdu 610041, Peoples R China

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2007年 / 274卷 / 1-2期

关键词：

demethylation; aryl methyl ethers; microwave irradiation;

D O I：

10.1016/j.molcata.2007.04.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A rapid method for the selective cleavage of aryl methyl ether in the lithium chloride-N,N-dimethylfortnamide (LiCl-DMF) system under microwave irradiation has been, developed. Effects of substituent, metal salt and solvent on the activity and selectivity in the cleavage reaction have been investigated. It is found that microwave significantly improves the reaction yield and the selectivity of demethylation for electron deficient aromatic methyl ethers. The catalytic mechanism of demethylation by LiCl salt is proposed. (c) 2007 Published by Elsevier B.V.

引用

页码：16 / 23

页数：8

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