Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-Binding protein

被引：22

作者：

Kang, AD

Wong, PMC

Chen, H

Castagna, R

Chung, SW

Sultzer, BM

机构：

[1] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOL BIOL, DEPT LAB MED & PATHOL, PHILADELPHIA, PA 19140 USA

[2] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOL BIOL, DEPT BIOCHEM, PHILADELPHIA, PA 19140 USA

[3] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOL BIOL, DEPT IMMUNOL & MICROBIOL, PHILADELPHIA, PA 19140 USA

[4] SUNY HLTH SCI CTR, DEPT MICROBIOL & IMMUNOL, MORSE INST MOL GENET, BROOKLYN, NY 11203 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 11期

关键词：

D O I：

10.1128/IAI.64.11.4612-4617.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous analysis of hybrid progeny derived from lipopolysaccharide (LPS) responder and nonresponder inbred mouse strains demonstrated that a single genetic locus controlled responsiveness to LPS, Using a differential functional screening approach, we report the isolation of a cDNA that has sequence homolog to a GTP-binding protein, Expression of the cDNA in splenic B cells of C3H/HeJ nonresponder, endotoxin-resistant mice resulted in polyclonal B-cell activation in response to LPS stimulation, Thus a GTP-binding protein may be involved in LPS stimulation in B cells and perhaps other cell types.

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收藏

页码：4612 / 4617

页数：6

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