Enhanced Ion Signals in Desorption Electrospray Ionization Using Surfactant Spray Solutions

被引：38

作者：

Badu-Tawiah, Abraham ^{[1
]}

Cooks, R. Graham ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2010年 / 21卷 / 08期

基金：

美国国家科学基金会;

关键词：

IMAGING MASS-SPECTROMETRY; AMBIENT CONDITIONS; DESI; DYNAMICS; MECHANISMS; LIQUIDS; TISSUES; SAMPLES; SOLIDS; DRUGS;

D O I：

10.1016/j.jasms.2010.04.001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Solvent optimization is an important procedure in desorption electrospray ionization (DESI) and in this study the effects of solvent surface tension are explored. Data are presented for methanol/water/surfactant solvent systems, which show increases in ion signals of more than an order of magnitude when low concentrations of surfactants are added to the standard methanol/water (1:1) spray solvent. Examples of analytes tested include food chemicals, peptides, pharmaceuticals, and drugs of abuse. The improvement in ion intensity is mainly attributed to the effect of surface tension in producing smaller spray droplets, which are shown to cover a larger surface area. Surfactant-containing spray solutions allowed extension of DESI-MS analysis to previously intractable analytes like melamine and highly hydrophobic compounds like the sudan dyes. (J Am Soc Mass Spectrom 2010, 21, 1423-1431) (C) 2010 American Society for Mass Spectrometry

引用

页码：1423 / 1431

页数：9

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