Scanning and surface alignment considerations in chemical imaging with desorption electrospray mass spectrometry

被引：45

作者：

Kertesz, Vilmos ^{[1
]}

van Berkel, Gary J. ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Organ & biol Mass Spect Grp, Div Chem Sci, Oak Ridge, TN 37831 USA

来源：

ANALYTICAL CHEMISTRY | 2008年 / 80卷 / 04期

关键词：

D O I：

10.1021/ac701947d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The effects of surface scanning mode (raster vs unidirectional scanning) and the constancy of spray tip-to-surface and atmospheric sampling interface capillary-to-surface distances on chemical image quality using desorption electrospray ionization mass spectrometry were investigated. Unidirectional scanning was found to provide a spatially and a quantitatively more precise chemical image of the surface as compared to raster scanning. Maintaining constant spray tip-to-surface and atmospheric sampling interface capillary-to-surface distances during an imaging experiment was found to also be critical. An automation process was implemented using a custom image analysis software (HandsFree Surface Analysis) to keep these distances constant during the surface sampling experiment. Improved chemical image quality afforded through this software control was illustrated by imaging printed objects on normal copy paper.

引用

页码：1027 / 1032

页数：6

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