An unusual mechanism for ligand antagonism

被引:132
作者
Torigoe, C [1 ]
Inman, JK
Metzger, H
机构
[1] NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA
[2] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1126/science.281.5376.568
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells.
引用
收藏
页码:568 / 572
页数:5
相关论文
共 39 条
[1]  
ALBER G, 1992, J IMMUNOL, V149, P2428
[2]  
ASHMAN RF, 1969, J BIOL CHEM, V244, P3405
[3]   ESTABLISHMENT OF 4 MOUSE MASTOCYTOMA CELL-LINES [J].
BARSUMIAN, EL ;
MCGIVNEY, A ;
BASCIANO, LK ;
SIRAGANIAN, RP .
CELLULAR IMMUNOLOGY, 1985, 90 (01) :131-141
[4]  
CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099
[5]   ANTIGEN VALENCY AS A DETERMINANT OF THE RESPONSIVENESS OF IGE-SENSITIZED RAT BASOPHIL LEUKEMIA-CELLS [J].
COLLINS, AM ;
THELIAN, D ;
BASIL, M .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (04) :547-556
[6]   .1. ASPECTS OF 2-COMPONENT IMMUNOLOGY - KINETICS OF REACTIONS BETWEEN ANTIBODIES TO 2,4 DINITROPHENYL GROUP AND SPECIFIC HAPTENS [J].
DAY, LA ;
STURTEVANT, JM ;
SINGER, SJ .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1963, 103 (02) :611-+
[7]  
ELIOT CW, 1985, FOLKLORE FABLES, P27
[8]   TICKLING THE TCR - SELECTIVE T-CELL FUNCTIONS STIMULATED BY ALTERED PEPTIDE LIGANDS [J].
EVAVOLD, BD ;
SLOANLANCASTER, J ;
ALLEN, PM .
IMMUNOLOGY TODAY, 1993, 14 (12) :602-609
[9]   PROTEOLYTIC DIGESTION OF MOUSE IGE [J].
HABA, S ;
NISONOFF, A .
JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 138 (01) :15-23
[10]   A REQUIREMENT FOR SYK IN THE ACTIVATION OF THE MICROTUBULE-ASSOCIATED PROTEIN-KINASE PHOSPHOLIPASE-A(2) PATHWAY BY FC-EPSILON-R1 IS NOT SHARED BY A G-PROTEIN-COUPLED RECEPTOR [J].
HIRASAWA, N ;
SCHARENBERG, A ;
YAMAMURA, H ;
BEAVEN, MA ;
KINET, JP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (18) :10960-10967