The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension

被引：154

作者：

Porcu, M ^{[1
]}

Chiarugi, A ^{[1
]}

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 02期

关键词：

D O I：

10.1016/j.tips.2004.12.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetylation of chromatin-interacting proteins is central to the epigenetic regulation of genome architecture and gene expression. Chemicals that modulate the acetylation of nuclear proteins have proved instrumental in experimental models of several human diseases. Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging. In this article, we focus on sirtuins and provide an appraisal of current compounds that either activate or inhibit sirtuin activity, highlighting their therapeutic potential for the treatment of human diseases.

引用

页码：94 / 103

页数：10

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