The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria

被引：34

作者：

Hombhanje, FW

Hwaihwanje, I

Tsukahara, T

Saruwatari, J

Nakagawa, M

Osawa, H

Paniu, MM

Takahashi, N

Lum, JK

Aumora, B

Masta, A

Sapuri, M

Kobayakawa, T

Kaneko, A

Ishizaki, T

机构：

[1] Univ Papua New Guinea, Sch Med & Hlth Sci, Port Moresby, Papua N Guinea

[2] Wewak Gen Hosp, Wewak, East Septik Pro, Papua N Guinea

[3] Tokyo Womens Med Univ, Dept Int Affairs & Trop Med, Tokyo, Japan

[4] Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Div Pharmacol & Therapeut, Kumamoto 860, Japan

[5] Dept Anthropol, Binghamton, NY USA

[6] Karolinska Inst, Dept Med, Stockholm, Sweden

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2005年 / 59卷 / 03期

关键词：

amodiaquine; desethylamodiaquine; CYP2C8;

D O I：

10.1111/j.1365-2125.2004.02257.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria. Methods AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method. Results AQ was not detectable beyond day 3 postdose. C-max for DEAQ was reached in 3.0 days. The mean values for t(1/2), MRT, and AUC(total) were 10.1 days, 15.5 days and 4512.6 mug l(-1) day, respectively. All the children were CYP2C8* homozygous. Conclusion Our data are consistent with those previously reported, and the AQ regimen seems pharmacokinetically adequate in the absence of CYP2C8 polymorphism.

引用

页码：298 / 301

页数：4

共 11 条

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