Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

被引：31

作者：

Vickerstaffe, E

Warrington, BH

Ladlow, M

Ley, SV

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 14期

关键词：

D O I：

10.1039/b305713e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.

引用

页码：2419 / 2422

页数：4

共 27 条

[1]

DORWALD FZ, 2000, ORGANIC SYNTHESIS SO

[2]

Drewry DH, 1999, MED RES REV, V19, P97, DOI 10.1002/(SICI)1098-1128(199903)19:2<97::AID-MED2>3.0.CO

[3]

2-Y

[4]

Flynn DL, 1999, MED RES REV, V19, P408, DOI 10.1002/(SICI)1098-1128(199909)19:5<408::AID-MED7>3.0.CO