Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

被引:31
作者
Vickerstaffe, E
Warrington, BH
Ladlow, M
Ley, SV
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Univ Cambridge, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England
关键词
D O I
10.1039/b305713e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.
引用
收藏
页码:2419 / 2422
页数:4
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