Very short and efficient syntheses of the spermine alkaloid kukoamine A and analogs using isolable succinimidyl cinnamates

被引：17

作者：

Garnelis, T

Athanassopoulos, CM

Papaioannou, D ^{[1
]}

Eggleston, IM

Fairlamb, AH

机构：

[1] Univ Patras, Dept Chem, GR-26500 Patras, Greece

[2] Univ Dundee, Fac Life Sci, Div Biol Chem & Mol Microbiol, Dundee DD1 4HN, Scotland

来源：

CHEMISTRY LETTERS | 2005年 / 34卷 / 02期

关键词：

D O I：

10.1246/cl.2005.264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct selective acylation of the primary amino functions of spen-nine and spermidine with a variety of isolable succinimidyl cinnamates. followed by catalytic hydrogenation, gave high yields of the spermine alkaloid kukoamine A and analogs suitable for structure-activity relationship studies. Suitable succinimidyl cinnamates were readily obtained through Wittig reaction of aromatic aldehydes with the ylides Ph3P=CRCO2Me, followed by saponification and activation with N-hydroxysuccinimide in the presence of N,N'-dicyclohexylcarbodiimide.

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页码：264 / 265

页数：2

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