Coronaviruses - drug discovery and therapeutic options

被引:1210
作者
Zumla, Alimuddin [1 ,2 ]
Chan, Jasper F. W. [3 ]
Azhar, Esam I. [4 ,5 ]
Hui, David S. C. [6 ,7 ]
Yuen, Kwok-Yung [3 ]
机构
[1] UCL, Div Infect & Immun, 307 Euston Rd, London NW1 3AD, England
[2] UCL Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, 307 Euston Rd, London NW1 3AD, England
[3] Univ Hong Kong, State Key Lab Emerging Infect Dis, Carol Yu Ctr Infect,Queen Mary Hosp, Res Ctr Infect & Immunol,Dept Microbiol, Univ Pathology Bldg,102 Pokfulam Rd, Pokfulam, Hong Kong, Peoples R China
[4] King Abdulaziz Univ, Special Infect Agents Unit, King Fahd Med Res Ctr, POB 128442, Jeddah 21362, Saudi Arabia
[5] King Abdulaziz Univ, Med Lab Technol Dept, Fac Appl Med Sci, POB 128442, Jeddah 21362, Saudi Arabia
[6] Chinese Univ Hong Kong, Prince Wales Hosp, Div Resp Med, 30-32 Ngan Shing St, Shatin, Hong Kong, Peoples R China
[7] Chinese Univ Hong Kong, Prince Wales Hosp, Stanley Ho Ctr Emerging Infect Dis, 30-32 Ngan Shing St, Shatin, Hong Kong, Peoples R China
基金
美国国家卫生研究院; 中国国家自然科学基金;
关键词
RESPIRATORY-SYNDROME CORONAVIRUS; RECEPTOR-BINDING DOMAIN; PAPAIN-LIKE PROTEASE; SARS-COV REPLICATION; ANGIOTENSIN-CONVERTING ENZYME-2; TRANSGENIC MOUSE MODEL; HOST-CELL ENTRY; MERS-COV; SPIKE PROTEIN; IN-VITRO;
D O I
10.1038/nrd.2015.37
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract infections, such as the common cold. By contrast, the CoVs responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which were discovered in Hong Kong, China, in 2003, and in Saudi Arabia in 2012, respectively, have received global attention over the past 12 years owing to their ability to cause community and health-care-associated outbreaks of severe infections in human populations. These two viruses pose major challenges to clinical management because there are no specific antiviral drugs available. In this Review, we summarize the epidemiology, virology, clinical features and current treatment strategies of SARS and MERS, and discuss the discovery and development of new virus-based and host-based therapeutic options for CoV infections.
引用
收藏
页码:327 / 347
页数:21
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