Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

被引：72

作者：

Boettler, Ute ^{[1
]}

Volz, Nadine ^{[1
]}

Pahlke, Gudrun ^{[1
]}

Teller, Nicole ^{[1
]}

Kotyczka, Christine ^{[2
]}

Somoza, Veronika ^{[2
,3
]}

Stiebitz, Herbert ^{[4
]}

Bytof, Gerhard ^{[4
]}

Lantz, Ingo ^{[4
]}

Lang, Roman ^{[5
]}

Hofmann, Thomas ^{[5
]}

Marko, Doris ^{[1
]}

机构：

[1] Univ Vienna, Dept Food Chem & Toxicol, A-1090 Vienna, Austria

[2] Deutsch Forsch Anstalt Lebensmittel, Garching, Germany

[3] Univ Vienna, A-1090 Vienna, Austria

[4] Tchibo GmbH, Hamburg, Germany

[5] Tech Univ Munich, Lehrstuhl Lebensmittelchem & Mol Sensor, Freising Weihenstephan, Germany

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2011年 / 55卷 / 05期

关键词：

Antioxidative; Coffee; Chemoprevention; Gene transcription; Nrf2; pathway; TRANSCRIPTION FACTOR NRF2; IDENTIFICATION; PLASMA; FOODS;

D O I：

10.1002/mnfr.201100115

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

引用

收藏

页码：798 / 802

页数：5

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