Preparation of Solid Salt-Stabilized Functionalized Organozinc Compounds and their Application to Cross-Coupling and Carbonyl Addition Reactions

被引：87

作者：

Bernhardt, Sebastian ^{[1
]}

Manolikakes, Georg ^{[2
]}

Kunz, Thomas ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

[2] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 39期

基金：

欧洲研究理事会;

关键词：

carbonyl addition; cross-coupling; Lewis acids; organozinc reagents; GRIGNARD-REAGENTS; ALKYLZINC HALIDES; DIRECT INSERTION; ARYL BROMIDES; ZINC; KETONES; PRECATALYST; MAGNESIUM; EFFICIENT; ARYLMAGNESIUM;

D O I：

10.1002/anie.201104291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Powdered organozinc reagents: Various aryl and heteroaryl bromides as well as benzylic chlorides react with Mg and Zn(OPiv)2·2 LiCl (OPiv=pivalate) to provide solid organozinc reagents after solvent evaporation. These powders can be stored at room temperature under argon for months and can be manipulated in air for a short time. They undergo smooth Negishi cross-coupling and carbonyl addition reactions (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9205 / 9209

页数：5

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