Antimycobacterial evaluation of germacranolides

被引：84

作者：

Fischer, NH ^{[1
]}

Lu, TS

Cantrell, CL

Castañeda-Acosta, J

Quijano, L

Franzblau, SG

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[3] Gwl Natl Hansens Dis Ctr, Lab Res Branch, Baton Rouge, LA 70894 USA

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 02期

关键词：

Sesquiterpene lactones; germacranolides; antimycobacterial activity; Mycobacterium tuberculosis; M-avium;

D O I：

10.1016/S0031-9422(98)00253-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The minimum inhibitory concentrations (MIC) against Mycobacterium tuberculosis and M. avium of parthenolide, costunolide, 1 (10)-epoxycostunolide and other germacranolide-type sesquiterpene lactones and derivatives were determined by use of a radiorespirometric bioassay. Structure-activity relationship studies with natural and semisynthetic sesquiterpene lactones suggested that the alpha-methylene-gamma-lactone moiety is an essential, but not sufficient, structural requirement for significant in vitro activity against M. tuberculosis and M. avium. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：559 / 564

页数：6

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