AAV loves an active genome

被引：24

作者：

Russell, DW ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

NATURE GENETICS | 2003年 / 34卷 / 03期

关键词：

D O I：

10.1038/ng0703-241

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Adeno-associated virus (AAV) holds much promise as a vector for gene therapy. Although transgene expression usually occurs from extrachromosomal vector genomes, vectors occasionally integrate into the host genome. A new study in normal mammalian cells shows that the insertions are associated with genomic deletions and occur preferentially in actively transcribed genes.

引用

页码：241 / 242

页数：2

共 13 条

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