Monitoring refractive index variations in turbid media using phase-sensitive frequency-domain OCT

被引：3

作者：

Larin, KV ^{[1
]}

Esenaliev, RO ^{[1
]}

Kim, E ^{[1
]}

Oh, S ^{[1
]}

Motamedi, M ^{[1
]}

Milner, TE ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Ctr Biomed Engn, Galveston, TX 77555 USA

来源：

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX | 2005年 / 5690卷

关键词：

OCT; swept-source; phase measurements;

D O I：

10.1117/12.590534

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Functional imaging of clear and tissue-simulating phantoms using phase-resolved swept-source spectroscopic OCT (PhS-SSOCT) is described. Superior sensitivity of PhS-SSOCT technique to monitor ultra-small changes in sample refractive index is demonstrated using aqueous solutions of glucose and aqueous suspensions of polystyrene microspheres and glucose. Glucose-induced changes in the phase are found to be 0.039 rad/mM and 0.037 rad/mM in the 200 mu m-thick cell for clear and turbid media, respectively, that is in good agreement with our previous data obtained using differential-phase time-domain OCT. Obtained results suggest that PhS-SSOCT has a potential for noninvasive, depth-resolved, real-time quantitative monitoring of concentrations of glucose and other analytes with high accuracy.

引用

页码：422 / 425

页数：4

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