Rh(II)-Catalyzed intermolecular oxidative sulfamidation of aldehydes:: A mild efficient synthesis of N-sulfonylcarboxamides

被引：86

作者：

Chan, Johann ^{[1
]}

Baucorn, Kyle D. ^{[1
]}

Murry, Jerry A. ^{[1
]}

机构：

[1] Amgen Inc, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 46期

关键词：

D O I：

10.1021/ja073872a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rh(II)-catalyzed oxidative coupling of aldehydes and sulfonamides has been developed to provide N -sulfonylcarboxamides in one step. A variety of sulfonamides were found to react with aromatic and aliphatic aldehydes to afford the desired products in good to excellent yields. Mechanistic data, including kinetic isotope effect experiments, suggest that the transformation proceeds through a concerted asynchronous nitrene insertion into an aldehydic hydrogen.

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页码：14106 / +

页数：3

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