Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release

被引:126
作者
Kyrsting, Anders [1 ]
Bendix, Poul M. [1 ]
Stamou, Dlinitrios G. [2 ,3 ]
Oddershede, Lene B. [1 ,3 ]
机构
[1] Univ Copenhagen, Niels Bohr Inst, DK-1168 Copenhagen, Denmark
[2] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-1168 Copenhagen, Denmark
[3] Univ Copenhagen, Lundbeck Fdn Ctr Biomembranes Nanomed, DK-1168 Copenhagen, Denmark
关键词
Gold nanoparticle; optical tweezers; heating; photothermal therapy; giant unilamellar vesicles; Lipid phase transition; surface plasmonics; PHASE-TRANSITION; DRUG-DELIVERY;
D O I
10.1021/nl104280c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Irradiated metallic nanoparticle hold great promise as heat transducers in-photothermal applications as drug delivery assays or photothermal therapy. We quantify the temperature increase of individual gold nanoparticles trapped in three dimensions near lipid vesicles exhibiting temperature sensitive permeability. The surface temperature can increase by hundreds of degrees Celsius even at moderate laser powers. Also, there are significant differences of the heat profiles in two-dimensional and three-dimensional trapping assays.
引用
收藏
页码:888 / 892
页数:5
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