Role of JNK activation in apoptosis: A double-edged sword

被引：631

作者：

Liu, J ^{[1
]}

Lin, AN ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

CELL RESEARCH | 2005年 / 15卷 / 01期

关键词：

JNK; NF-kappa B; apoptosis; TNF-alpha; IL-3;

D O I：

10.1038/sj.cr.7290262

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-kappaB activation, prolonged JNK activation contributes to TNF-alpha induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways.

引用

页码：36 / 42

页数：7

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