Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer

被引：105

作者：

Mueller, Jens ^{[1
,2
]}

Wulffen, Bernhard

Poetzsch, Bernd ^{[1
]}

Mayer, Gunter ^{[2
]}

机构：

[1] Univ Bonn, Inst Expt Haematol & Transfus Med, D-53127 Bonn, Germany

[2] Univ Bonn, Kekule Inst Organ Chem & Biochem, Program Unit Chem Biol & Med Chem, LIMES, D-5300 Bonn, Germany

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 18期

关键词：

aptamers; bivalent ligands; coagulation; thrombin;

D O I：

10.1002/cbic.200700535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2223 / 2226

页数：4

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