Fluorescent dyes specific for quadruplex DNA

被引：289

作者：

Arthanari, H ^{[1
]}

Basu, S ^{[1
]}

Kawano, TL ^{[1
]}

Bolton, PH ^{[1
]}

机构：

[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA

来源：

NUCLEIC ACIDS RESEARCH | 1998年 / 26卷 / 16期

关键词：

D O I：

10.1093/nar/26.16.3724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorescent dyes which are specific for duplex DNA have found a wide range of applications from staining gels to visualization of chromosomes. Porphyrin dyes have been found which are highly fluorescent in the presence of quadruplex but not duplex DNA, These dyes may offer a route to the specific detection of quadruplex DNA under biologically important conditions. There are three types of DNA quadruplex structures, and these may play important roles in telomere, centromere, triplet repeat, integration sites and other DNAs, and this first set of porphyrin dyes show some selectivity between the quadruplex types.

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页码：3724 / 3728

页数：5

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