Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses

被引：35

作者：

Dekker, S

Toussaint, W

Panayotou, G

de Wit, T

Visser, P

Grosveld, F

Drabek, D

机构：

[1] Erasmus MC Rotterdam, Fac Med, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] Biomed Sci Res Ctr Alexander Fleming, Varkiza 16602, Greece

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 22期

关键词：

D O I：

10.1128/JVI.77.22.12132-12139.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.

引用

收藏

页码：12132 / 12139

页数：8

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