Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles

被引：18

作者：

Basha, Shaik Sharafuddin ^{[1
]}

Ramachandra Reddy, Putta ^{[1
]}

Padmaja, Adivireddy ^{[1
]}

Padmavathi, Venkatapuram ^{[1
]}

Mouli, Kalla Chandra ^{[2
]}

Vijaya, Tartte ^{[2
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Sri Venkateswara Univ, Dept Bot, Tirupati 517502, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 03期

关键词：

Thiazoles; Pyrazoles; Pyrroles; 1,3-Dipolar cycloaddition; Antimicrobial activity; BIOLOGICAL-ACTIVITY; DIAZOCARBONYL COMPOUNDS; DERIVATIVES; CYCLOADDITION; ANTICANCER; DESIGN; ANTIBACTERIAL; SELECTIVITY; THIAZOLES; LIGANDS;

D O I：

10.1007/s00044-014-1169-8

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A variety of bis heterocycles-heteroaryl pyrazoles (5) and pyrroles (6) were prepared from heteroaryl chalcones adopting 1,3-dipolar cycloaddition reaction and studied their antimicrobial activity. The compounds 5d and 5f having bromo and nitro substituents on the aromatic ring are the potent antimicrobial agents against Bacillus subtilis and Aspergillus niger.

引用

页码：954 / 964

页数：11

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