SARS vaccine development

被引：154

作者：

Jiang, SB ^{[1
]}

He, YX ^{[1
]}

Liu, SW ^{[1
]}

机构：

[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10021 USA

来源：

EMERGING INFECTIOUS DISEASES | 2005年 / 11卷 / 07期

关键词：

D O I：

10.3201/1107.050219

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.

引用

页码：1016 / 1020

页数：5

共 39 条

[1] Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice [J].

Bisht, H ;

Roberts, A ;

Vogel, L ;

Bukreyev, A ;

Collins, PL ;

Murphy, BR ;

Subbarao, K ;

Moss, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6641-6646

[2] Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS [J].

Bukreyev, A ;

Lamirande, EW ;

Buchholz, UJ ;

Vogel, LN ;

Elkins, WR ;

St Claire, M ;

Murphy, BR ;

Subbarao, K ;

Collins, PL .

LANCET, 2004, 363 (9427) :2122-2127

[3] Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region [J].

Chen, ZW ;

Zhang, LQ ;

Qin, CA ;

Ba, L ;

Yi, CE ;

Zhang, FW ;

Wei, Q ;

He, T ;

Yu, WJ ;

Yu, J ;

Gao, H ;

Tu, XM ;

Gettie, A ;

Farzan, M ;

Yuen, KY ;

Ho, DD .

JOURNAL OF VIROLOGY, 2005, 79 (05) :2678-2688

[4] Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) [J].

Chou, THW ;

Wang, SX ;

Sakhatskyy, PV ;

Mboudoudjeck, I ;

Lawrence, JM ;

Huang, S ;

Coley, S ;

Yang, BA ;

Li, JM ;

Zhu, QY ;

Lu, S .

VIROLOGY, 2005, 334 (01) :134-143

[5] The secret life of ACE2 as a receptor for the SARS virus [J].

Dimitrov, DS .

CELL, 2003, 115 (06) :652-653

[6] Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome [J].

Guan, Y ;

Peiris, JSM ;

Zheng, B ;

Poon, LLM ;

Chan, KH ;

Zeng, FY ;

Chan, CWM ;

Chan, MN ;

Chen, JD ;

Chow, KYC ;

Hon, CC ;

Hui, KH ;

Li, J ;

Li, VYY ;

Wang, Y ;

Leung, SW ;

Yuen, KY ;

Leung, FC .

LANCET, 2004, 363 (9403) :99-104

[7] Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China [J].

Guan, Y ;

Zheng, BJ ;

He, YQ ;

Liu, XL ;

Zhuang, ZX ;

Cheung, CL ;

Luo, SW ;

Li, PH ;

Zhang, LJ ;

Guan, YJ ;

Butt, KM ;

Wong, KL ;

Chan, KW ;

Lim, W ;

Shortridge, KF ;

Yuen, KY ;

Peiris, JSM ;

Poon, LLM .

SCIENCE, 2003, 302 (5643) :276-278

[8] Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China [J].

He, JF ;

Peng, GW ;

Min, J ;

Yu, DW ;

Liang, WJ ;

Zhang, SY ;

Xu, RH ;

Zheng, HY ;

Wu, XW ;

Xu, J ;

Wang, ZH ;

Fang, L ;

Zhang, X ;

Li, H ;

Yan, XG ;

Lu, JH ;

Hu, ZH ;

Huang, JC ;

Wan, ZY ;

Hou, JL ;

Lin, JY ;

Song, HD ;

Wang, SY ;

Zhou, XJ ;

Zhang, GW ;

Gu, BW ;

Zheng, HJ ;

Zhang, XL ;

He, M ;

Zheng, K ;

Wang, BF ;

Fu, G ;

Wang, XN ;

Chen, SJ ;

Chen, Z ;

Hao, P ;

Tang, H ;

Ren, SX ;

Zhong, Y ;

Guo, ZM ;

Liu, Q ;

Miao, YG ;

Kong, XY ;

He, WZ ;

Li, YX ;

Wu, CI ;

Zhao, GP ;

Chiu, RWK ;

Chim, SSC ;

Tong, YK .

SCIENCE, 2004, 303 (5664) :1666-1669

[9] Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies [J].

He, YX ;

Lu, H ;

Siddiqui, P ;

Zhou, YS ;

Jiang, SB .

JOURNAL OF IMMUNOLOGY, 2005, 174 (08) :4908-4915

[10] Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: Importance for designing SARS vaccines [J].

He, YX ;

Zhu, QY ;

Liu, SW ;

Zhou, YS ;

Yang, BA ;

Li, JM ;

Jiang, SB .

VIROLOGY, 2005, 334 (01) :74-82

← 1 2 3 4 →