The molecular basis of thyroid epithelial tumorigenesis

被引：13

作者：

Bongarzone, I ^{[1
]}

Pierotti, MA ^{[1
]}

机构：

[1] NCI, Dept Expt Oncol, Milan, Italy

来源：

TUMORI | 2003年 / 89卷 / 05期

关键词：

changes in molecular biology; thyroid cancer; tumorigenesis;

D O I：

10.1177/030089160308900510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Significant alterations in gene sequences, expression levels and protein structures have been associated with specific types of thyroid epithelial tumorigenesis. Recent revolutionary changes in molecular biology have spanned the disciplines of genomics and proteomics, which systematically generate and analyze the information about genomes, gene transcripts, proteins and their functions in a global, comprehensive manner. The application of these approaches will better discriminate between thyroid tumor subtypes that are not recognizable when traditional pathological criteria are used.

引用

页码：514 / 516

页数：3

共 20 条

[1] RET and NTRK1 proto-oncogenes in human diseases [J].

Albert, L ;

Carniti, C ;

Miranda, C ;

Roccato, E ;

Pierotti, MA .

JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (02) :168-186

[2] The molecular basis of thyroid epithelial tumorigenesis [J].

Bongarzone, I ;

Pierotti, MA .

TUMORI, 2003, 89 (05) :514-516

[3]

Bunone G, 2000, CANCER RES, V60, P2845

[4] Detection of the PAX8-PPARγ fusion oncogene in both follicular thyroid carcinomas and adenomas [J].

Cheung, L ;

Messina, M ;

Gill, A ;

Clarkson, A ;

Learoyd, D ;

Delbridge, L ;

Wentworth, J ;

Philips, J ;

Clifton-Bligh, R ;

Robinson, BG .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :354-357

[5] Laser capture microdissection [J].

EmmertBuck, MR ;

Bonner, RF ;

Smith, PD ;

Chuaqui, RF ;

Zhuang, ZP ;

Goldstein, SR ;

Weiss, RA ;

Liotta, LA .

SCIENCE, 1996, 274 (5289) :998-1001

[6] Prevalence of Ras mutations in thyroid neoplasia [J].

Esapa, CT ;

Johnson, SJ ;

Kendall-Taylor, P ;

Lennard, TWJ ;

Harris, PE .

CLINICAL ENDOCRINOLOGY, 1999, 50 (04) :529-535

[7] Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells [J].

Fournes, B ;

Monier, R ;

Michiels, F ;

Milgrom, E ;

Misrahi, M ;

Feunteun, J .

ONCOGENE, 1998, 16 (08) :985-990

[8]

Görg A, 2000, ELECTROPHORESIS, V21, P1037, DOI 10.1002/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO

[9]

2-V

[10]

Hanash SM, 2000, ELECTROPHORESIS, V21, P1202, DOI 10.1002/(SICI)1522-2683(20000401)21:6<1202::AID-ELPS1202>3.3.CO

← 1 2 →