Plasma membrane disruption: Repair, prevention, adaptation

被引:375
作者
McNeil, PL [1 ]
Steinhardt, RA
机构
[1] Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA
[2] Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA
[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
关键词
exocytosis; injury; fusion; calcium; resealing;
D O I
10.1146/annurev.cellbio.19.111301.140101
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response to disruption. Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages. Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms.
引用
收藏
页码:697 / 731
页数:37
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