α,β-Diamino acids:: Biological significance and synthetic approaches

被引：279

作者：

Viso, A ^{[1
]}

de la Pradilla, RF ^{[1
]}

García, A ^{[1
]}

Flores, A ^{[1
]}

机构：

[1] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 08期

关键词：

D O I：

10.1021/cr0406561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Through the years, α,β-diamino acids and their derivative esters and amides have attracted a great deal of attention among organic chemists and biochemists. This review deals with the biological significance, the therapeutic uses, and other interesting applications of α,β-diamino acids and their derivatives found in the existing literature. The aim is to provide a deep and general view of the existing methodology for the synthesis of aliphatic α,β- or 2,3-diamino acids and their simple derivatives, esters or amides.

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页码：3167 / 3196

页数：30

相关论文

共 381 条

[1] THERMAL-ISOMERIZATION OF N-OXALYL DERIVATIVES OF DIAMINO ACIDS [J].

ABEGAZ, BM ;

NUNN, PB ;

DEBRUYN, A ;

LAMBEIN, F .

PHYTOCHEMISTRY, 1993, 33 (05) :1121-1123

[2] A novel approach for the solid-phase synthesis of substituted cyclic guanidines, their respective bis analogues, and N-acylated guanidines from N-acylated amino acid amides [J].

Acharya, AN ;

Ostresh, JM ;

Houghten, RA .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (06) :578-589

[3] Solid-phase synthesis of substituted imidazoline-tethered 2,3-diketopiperazines, cyclic ureas, and cyclic thioureas [J].

Acharya, AN ;

Ostresh, JM ;

Houghten, RA .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (06) :612-623

[4] SYNTHESIS AND NMDA ANTAGONISTIC PROPERTIES OF THE ENANTIOMERS OF 4-(3-PHOSPHONOPROPYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP) AND OF THE UNSATURATED ANALOG (E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP-ENE) [J].

AEBISCHER, B ;

FREY, P ;

HAERTER, HP ;

HERRLING, PL ;

MUELLER, W ;

OLVERMAN, HJ ;

WATKINS, JC .

HELVETICA CHIMICA ACTA, 1989, 72 (05) :1043-1051

[5] Novel catalytic and asymmetric process for aziridination mediated by sulfur ylides [J].

Aggarwal, VK ;

Thompson, A ;

Jones, RVH ;

Standen, MCH .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (24) :8368-8369

[6] A new enantioselective synthesis of N-arylaziridines by phase-transfer catalysis [J].

AiresdeSousa, J ;

Lobo, AM ;

Prabhakar, S .

TETRAHEDRON LETTERS, 1996, 37 (18) :3183-3186

[7] 4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis [J].

Alcaide, B ;

Almendros, P .

CHEMICAL SOCIETY REVIEWS, 2001, 30 (04) :226-240

[8] Cycloadditions of aromatic imines to enantiomerically pure stabilized azomethine ylids:: Construction of threo (2S,3R)-3-aryl-2,3-diamino acids [J].

Alker, D ;

Harwood, LM ;

Williams, CE .

TETRAHEDRON LETTERS, 1998, 39 (5-6) :475-478

[9] Asymmetric oxidative dimerization of the enolates of N-[bis(methylthio)methylene]- and N-(diphenylmethylene)glycine esters [J].

AlvarezIbarra, C ;

Csaky, AG ;

Colmenero, B ;

Quiroga, ML .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) :2478-2482

[10]

Ambroise L, 2002, SYNTHESIS-STUTTGART, P2296

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