α,β-Diamino acids:: Biological significance and synthetic approaches

被引：279

作者：

Viso, A ^{[1
]}

de la Pradilla, RF ^{[1
]}

García, A ^{[1
]}

Flores, A ^{[1
]}

机构：

[1] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 08期

关键词：

D O I：

10.1021/cr0406561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Through the years, α,β-diamino acids and their derivative esters and amides have attracted a great deal of attention among organic chemists and biochemists. This review deals with the biological significance, the therapeutic uses, and other interesting applications of α,β-diamino acids and their derivatives found in the existing literature. The aim is to provide a deep and general view of the existing methodology for the synthesis of aliphatic α,β- or 2,3-diamino acids and their simple derivatives, esters or amides.

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页码：3167 / 3196

页数：30

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