Bilateral striatal necrosis, dystonia and multiple mitochondrial DNA deletions: Case study and effect of deep brain stimulation

被引：27

作者：

Aniello, Maria Stella ^{[1
]}

Martino, Davide ^{[1
]}

Petruzzella, Vittoria ^{[2
,3
]}

Eleopra, Roberto ^{[4
]}

Mancuso, Michelangelo ^{[5
]}

Dell'Aglio, Rosa ^{[2
]}

Cavallo, Michele ^{[6
]}

Siciliano, Gabriele ^{[5
]}

Defazio, Giovanni ^{[1
]}

机构：

[1] Univ Bari, Dept Neurol & Psychiat Sci, I-70124 Bari, Italy

[2] Univ Bari, Dept Med Biochem Med Biol & Med Phys, I-70124 Bari, Italy

[3] CNR, Italian Res Council, Inst Biomembranes & Bioenerget, I-00185 Rome, Italy

[4] Osped Umberto 1, Neurol Unit, Venice Mestre, Italy

[5] Univ Pisa, Dept Neurosci, Neurol Clin, Pisa, Italy

[6] St Anna Hosp, Neurosurg Unit, Ferrara, Italy

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 01期

关键词：

bilateral striatal necrosis; mitochondrial DNA; dystonia; deep brain stimulation;

D O I：

10.1002/mds.21760

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Bilateral striatal necrosis (BSN) is relatively rare and has been related to a wide array of causes, including nuclear and mitochondrial DNA mutations. We report the clinical vignette of a patient with a 37 years-history of generalized dystonia secondary to BSN associated with multiple mitochondrial DNA deletions of undefined origin. Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability. (c) 2007 Movement Disorder Society.

引用

页码：114 / 118

页数：5

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