Creating immune privilege: active local suppression that benefits friends, but protects foes

被引：254

作者：

Mellor, Andrew L.

Munn, David H.

机构：

[1] Andrew L. Mellor and David H. Munn are at the Immunotherapy and Cancer Centers,

[2] Medical College of Georgia,undefined

[3] Augusta,undefined

[4] Georgia USA.,undefined

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 01期

关键词：

D O I：

10.1038/nri2233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How do antigenic tumour cells and chronic pathogens exploit natural regulatory mechanisms to become non-immunogenic? Andrew Mellor and David Munn propose that such immune unresponsiveness is an indirect consequence of the need to control the potentially lethal consequences of unrestrained immunity to innocuous substances.

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页码：74 / 80

页数：7

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