An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

被引:89
作者
Iwabuchi, Y [1 ]
Sugihara, T [1 ]
Esumi, T [1 ]
Hatakeyama, S [1 ]
机构
[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan
基金
日本学术振兴会;
关键词
D O I
10.1016/S0040-4039(01)01676-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An enantio- and stereocontrolled route to epopromycin B having the epoxy-beta -aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码:7867 / 7871
页数:5
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